Biognost-Euroimmun-Auto-immuniteit-autoimmuniteit

Auto-immuniteit

Een ruim gamma aan testen voor de diagnose van o.a. vasculitis, CTD, gastroenterology, autoimmune liver diseases, endocrinology, neurology en dermatology.

Rheumatology

Collagenoses/Connective tissue diseases

ELISAImmunoblotIFTMicroArray
Cell components (ANA)  * 
nRNP / Sm***
nRNP70, A, C**
Sm***
SS-A (Ro, 60 kDa)***
SS-B (La)***
Scl-70***
Jo-1***
Ribosomal P-proteins***
Centromeres (CENP A)**
Centromeres (CENP B)***
PM-Scl75**
PM-Scl100***
dsDNA***
Histones***
Nucleosomes***
ssDNA**
Ro-52***
Proliferating cell nuclear antigen (PCNA, cyclin 1)***
Mitosin (CENP-F)*
Ku**
Mi-2α, Mi-2β**
Signal recognition particle (SRP)**
PL-7, PL-12, EJ, OJ**
Platelet-derived growth factor receptor (PDGFR)*
Th / To*
NOR-90**
Fibrillarin**
RNA polymerase III (RP155, RP11)**
Circulating immune complexes (CIC)*
TIF1ϒ**
MDA5*
NXP2*
SAE1*
cN-1A**
DFS70***

 

Rheumatoid arthritis

ELISAImmunoblotIFTMicroArray
Cyclic citrullinated peptides (CCP)*
Rheumatoid factor (RF)*
Filaggrin (RA keratin)*
Sa*
Citrullinated alpha-enolase peptide 1 (CEP-1)*

 

Antiphospholipid syndrome (APS)

ELISAImmunoblotIFTMicroArray
Cardiolipin*
β2-glycoprotein 1*
Phosphatidylserine*

Vasculitis / Nephrology

ELISAImmunoblotIFTMicroArrayChLIA
Granulocyte cytoplasm (ANCA)*
Proteinase 3 (PR3)****
Myeloperoxidase (MPO)***
Elastase**
Cathepsin G**
Bactericidal permeability-increasing protein (BPI)**
Lactoferrin**
Lysozyme*
Glomerular basement membrane (GBM)***
Renal tubule basement membrane*
Alveolar basement membrane*
Phospholipase A2 receptor (PLA2R)***
Thrombospondin type-1 domain-containing protein 7A (THSD7A)*

 

Gastroenterology

Pernicious anaemia

ELISAImmunoblotIFTMicroArray
Parietal cells (PCA)**
Intrinsic factor (IF)**
Parietal cell antigen ATP4B (beta-subunit of H+/K+-ATPase)*

 

Coeliac disease (gluten-sensitive enteropathy)

ELISAImmunoblotIFTMicroArray
Deamidated gliadin (GAF-3X)***
Endomysium (EmA)*
Tissue transglutaminase (tTG)***

 

Chronic inflammatory bowel diseases

ELISAImmunoblotIFTMicroArray
Pancreas acini (CUZD1 and GP2)*
Intestinal goblet cells (BAk)*
Saccharomyces cerevisiae**
DNA-bound lactoferrin (LFS-granulocytes)*

 

Autoimmune liver diseases

 

ELISAImmunoblotIFTMicroArray
Smooth muscles (SMA, type actin)*
Soluble liver antigen / liver-pancreas antigen (SLA / LP)***
Cytosolic liver antigen type 1 (LC-1)***
Liver-kidney microsomes (LKM-1)***
AMA M2-3E***
Nuclear dots*
Sp100**
PML**
Nuclear membrane*
gp210**
p62*
Lamins*
pANCA (granulocytes)*

 

Endocrinology

Diabetes

ELISAImmunoblotIFTMicroArray
Pancreas islets (ICA)*
Glutamic acid decarboxylase (GAD)**
Tyrosine phosphatase (IA2)**
Zinc transporter 8 (ZnT8)**

 

Autoimmune thyroid diseases

ELISAImmunoblotIFTMicroArray
Thyroid peroxidase (TPO)**
Thyroglobulin (TG)**
TSH receptor (thyrotropin receptor)*

 

Autoimmune polyendocrinopathy / Infertility

ELISAImmunoblotIFTMicroArray
Parathyroid gland*
Adrenal cortex*
Ovary*
Placenta*
Pituitary gland*
Hypothalamus*
Spermatozoa*
Testis / Leydig cells*
Uterus*

 

Neurology

Paraneoplastic syndrome

ELISAImmunoblotIFTMicroArray
Hu (ANNA-1)**
Yo (PCA-1)**
Ri (ANNA-2)**
Amphiphysin**
CV2 (CRMP5)**
Ma (Ma1, Ma2 / Ta)**
PCA-2*
Tr (DNER)**
ITPR1*
CARP*
SOX1**
Glutamic acid decarboxylase (GAD)***
Titin**
Recoverin**
Zic4**

 

Receptor & membrane proteins

ELISAImmunoblotIFTMicroArray
Aquaporin-4 (NMO-IgG)*
Myelin oligodendrocyte glycoprotein (MOG)*
mGLUR5 – Flotillin*
Glutamate receptors (types NMDA and AMPA)*
GABAB receptors*
VGKC associated proteins (LGI1, CASPR2)*
DPPX*
IgLON5*

 

Other parameters

ELISAImmunoblotIFTMicroArray
Gangliosides (GM1, GM2, GM3, GD1a, GD1b, GT1b, GQ1b)*
Myelin*
Myelin-associated glycoprotein (MAG)*
Hippocampus*
Cerebrum*
Cerebellum*
Peripheral nerves*
Spinal marrow*
Optic nerve*
Striated muscles*
Acetylcholine receptor**
Muscle-specific tyrosine kinase (MuSK)*
GFAP*
Synaptophysin*
Neuroendothelium*

Dermatology

ELISAImmunoblotIFTMicroArray
Epidermal basement membrane (EBM)*
BP180**
BP230**
Desmosomes*
Desmoglein 1**
Desmoglein 3**
Envoplakin**
Salt-split skin*
Transitional epithelium*
Collagen type VII**
Laminin 332*
Tissue transglutaminase (tTG)**
Endomysium (EmA)*
Deamidated gliadin (GAF-3X)***

 

Automatisatie

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